The direction and specificity of endolysosomal membrane trafficking is tightly regulated by various cytosolic and membrane‐bound factors, including soluble NSF attachment protein receptors (SNAREs), Rab GTPases, and phosphoinositides. Another trafficking regulatory factor is juxta‐organellar Ca2+, which is hypothesized to be released from the lumen of endolysosomes and to be present at higher concentrations near fusion/fission sites. The recent identification and characterization of several Ca2+ channel proteins from endolysosomal membranes has provided a unique opportunity to examine the roles of Ca2+ and (...) Ca2+ channels in the membrane trafficking of endolysosomes. SNAREs, Rab GTPases, and phosphoinositides have been reported to regulate plasma membrane ion channels, thereby suggesting that these trafficking regulators may also modulate endolysosomal dynamics by controlling Ca2+ flux across endolysosomal membranes. In this paper, we discuss the roles of phosphoinositides, Ca2+, and potential interactions between endolysosomal Ca2+ channels and phosphoinositides in endolysosomal dynamics. (shrink)

An integrated hog futures price forecasting model based on whale optimization algorithm, LightGBM, and Complete Ensemble Empirical Mode Decomposition with Adaptive Noise is proposed to overcome the limitations of a single machine learning model with low prediction accuracy and insufficient model stability. The simulation process begins with a grey correlation analysis of the hog futures price index system in order to identify influencing factors; after that, the WOA-LightGBM model is developed, and the WOA algorithm is used to optimize the LightGBM (...) model parameters; and, finally, the residual sequence is decomposed and corrected by using the CEEMDAN method to build a combined WOA-LightGBM-CEEMDAN model. Furthermore, it is used for comparison experiments to check the validity of the model by using data from CSI 300 stock index futures. Based on all experimental results, the proposed combined model shows the highest prediction accuracy, surpassing the comparative model. The model proposed in this study is accurate enough to meet the forecasting accuracy requirements and provides an effective method for forecasting future prices. (shrink)

This volume brings the first English translation of the Confucian classics Four Books for Women, with extensive commentaries, to the English-speaking world. Written by women for women's education, this work provides an invaluable look at the tradition of Chinese women's writing, education, history, and philosophy, from the 1st to the 16th century.

Most previous empirical studies just addressed the influence of geographical proximity on interactive learning regarding the collaboration between knowledge-intensive business service and manufacturing industries. Drawing upon the social cognitive and knowledge-based perspective, this study bridged the research gaps by investigating the joint effects of geographical proximity and two representative non-geographic-proximities in fostering manufacturing firms’ innovation performance. In terms of the empirical analysis, we applied a research sample that involves the data of various manufacturing industries in 260 cities of China from (...) 2003 to 2014 to test the corresponding hypotheses. Additionally, the Spatial Durbin Model was adopted and the research findings showed that: the geographic and social proximity significantly promote the knowledge transfer from KIBS to manufacturing firms, which further improves the innovation performance of the latter. However, the effect of cognitive proximity presents insignificant; the interactive effect of geographic and social proximity was positively associated with the innovation collaboration between KIBS and manufacturing firms; although the individual effect of cognitive proximity was insignificant, when it interacted with geographic or social proximity, the joint effects were proved to promote the innovation performance of manufacturing firms. This study extends our understanding pertaining to the influencing mechanism of proximity for KIBS and the innovation process. The findings proved that geographic and social proximity are two imperative facilitators of knowledge-creating collaboration, highlighting their indispensable role in moderating and mediating the knowledge transfer of KIBS as well as the innovation performance of manufacturing firms. Notably, cognitive proximity is contingent upon geographic and social proximity on its positive effects on the innovation performance for KIBS and their clients’ collaboration. (shrink)

The increase of ETC vehicles on expressways has changed the proportion of ETC/MTC lanes at toll stations. Based on a driving simulator, three toll gate lane warning sign schemes were proposed in this study. Driving simulation experiments were conducted to study the influence of figures in warning signs at the manual toll station on the lane change timing of drivers. It was found that the addition of arrows to the warning signs can significantly shorten the response time and guide the (...) driver to make lane change decisions earlier to reduce the congestion between MTC vehicles and the mainline ETC vehicles at the toll plaza, thereby improving the traffic capacity and safety. (shrink)